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Nutrient Review for Neurological and Mood Health: Zinc

Risk Factors for Deficiency: Malabsorption, alcoholics, vegetarians, pregnant/lactating women, inadequate intake (cancer, anorexia nervosa)

Signs of Deficiency: Weight loss, taste abnormalities, and mental lethargy

RDA: 8mg (female), 11mg (male) +3mg (pregnancy) +1mg (lactation)


Recent Research

The serum zinc concentration as a potential biological marker in patients with major depressive disorder.
Zinc in drug-naïve patients with short-illness-duration first episode major depressive disorder: impact on psychopathological features.
Potential roles of zinc in the pathophysiology and treatment of major depressive disorder.
The role of zinc in neurodegenerative inflammatory pathways in depression.
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity.
Zinc in the Glutamatergic Theory of Depression.
Dietary zinc and iron intake and risk of depression: A meta-analysis.
Behavioral Abnormality Induced by Enhanced Hypothalamo-Pituitary-Adrenocortical Axis Activity under Dietary Zinc Deficiency and Its Usefulness as a Model.
Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study.
Lower Serum Zinc and Higher CRP Strongly Predict Prenatal Depression and Physio-somatic Symptoms, Which All Together Predict Postnatal Depressive Symptoms.
Increasing iron and zinc in pre-menopausal women and its effects on mood and cognition: a systematic review.
Biological consequences of zinc deficiency in the pathomechanisms of selected diseases.
Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc.
Effects of zinc supplementation in patients with major depression: a randomized clinical trial.
Dietary intake of zinc was inversely associated with depression.

About Sarah Ferreira

Sarah Ferreira,MS,MPH,RD,CDN,CNSC,IFNCP,CHWC is a Registered Dietitian Nutritionist with complementary certification as an Integrative and Functional Nutrition Certified Practitioner and Certified Health and Wellness Coach. She is the owner of Mindfully Nourished Solutions, where she uses a whole-person, whole-food approach to explore the impact of nutrition on mood and cognition. Her individualized approach integrates an assessment of nutritional, genetic, environmental, and lifestyle factors into a collaborative nutrition care plan using cutting-edge research designed to facilitate meaningful and restorative changes based around client goals and priorities.

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