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Nutrient Review for Neurological and Mood Health: B12

Risk Factors: Prolonged medication use, Histamine H2 blocker use for more than 12 months, Metformin use for more than four months, Proton pump inhibitor use for more than 12 months, Decreased ileal absorption, Crohn disease, Ileal resection, Inadequate intake, Alcohol abuse, Patients older than 75 years, Vegans or strict vegetarians, Decreased intrinsic factor, Atrophic gastritis, Pernicious anemia, Postgastrectomy syndrome (includes Roux-en-Y gastric bypass)

Top food sources include: Clams, Liver, Beef, Rainbow trout, Salmon & Tunafish

Signs of Deficiency: Cognitive Impairment, Confusion, Poor Memory, Hallucination, Manic & Schizophrenic State, Dementia-Like Symptoms, Acute Psychosis, Gait Abnormalities, Irritability, Peripheral Neuropathy

Needed for: Synthesis for monoamine neurotransmitters, Myelin sheaths on nerves, Folate metabolism

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Recent Studies of Interest 

Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial. 

The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

Neuropsychiatric and neurological problems among Vitamin B12 deficient young vegetarians.
Kynurenine pathway is altered in patients with SLE and associated with severe fatigue.
Association between Serum Vitamin Levels and Depression in U.S. Adults 20 Years or Older Based on National Health and Nutrition Examination Survey 2005⁻2006.
Increased risk of cognitive impairment in patients with diabetes is associated with metformin.
Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis.
Molecular mechanisms of depression: perspectives on new treatment strategies.
Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin.
Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression.
The Effects of Vitamin B in Depression.
Associations between holotranscobalamin, vitamin B12, homocysteine and depressive symptoms in community-dwelling elders.
B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial.
B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline.
Vitamin B12 Deficiency and Elevated Folate Levels: An Unusual Cause of Generalized Tonic-Clonic Seizure.
Neuropsychiatric manifestations ushering pernicious anemia
Acute psychotic depression as a sole manifestation of vitamin B12 deficiency.

About Sarah Ferreira

Sarah Ferreira,MS,MPH,RD,CDN,CNSC,IFNCP,CHWC is a Registered Dietitian Nutritionist with complementary certification as an Integrative and Functional Nutrition Certified Practitioner and Certified Health and Wellness Coach. She is the owner of Mindfully Nourished Solutions, where she uses a whole-person, whole-food approach to explore the impact of nutrition on mood and cognition. Her individualized approach integrates an assessment of nutritional, genetic, environmental, and lifestyle factors into a collaborative nutrition care plan using cutting-edge research designed to facilitate meaningful and restorative changes based around client goals and priorities.

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